Abstract
Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. Usually, the number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. Nevertheless, in some instances, associated pilar abnormalities have been reported. We here report 2 cases of NLS with disorganized pilosebaceous units. The follicular structures were dilated and showed infundibular type keratinization and there were numerous mature sebaceous lobules radiating from them resembling the histology of a folliculosebaceous cystic hamartoma (FSCH) or a sebaceous trichofolliculoma. Only 2 cases of NLS with FSCH have been previously reported. Our cases represent examples of a very rare hamartomatous cutaneous lesion composed of mesenchymal and epithelial components.
Highlights
Nevus lipomatosus superficialis (NLS) is an uncommon cutaneous hamartoma consisting of flesh-colored or yellowish soft nodules or papules with smooth or wrinkled surface, which are histologically composed of groups of mature fat cells located among the bundles of dermal collagen
We report 2 cases of cutaneous hamartoma consisting of clusters of mature fat cells located among the collagen bundles of the dermis and disorganized infundibular structures with numerous radiating well-developed sebaceous glands
folliculosebaceous cystic hamartoma (FSCH) is a rare developmental cutaneous abnormality formed by dilated and distorted folliculosebaceous units embedded in a stroma containing spindle and stellate fibroblasts, and variable amounts of mature fat cells, blood vessels, nerves, and mucin
Summary
Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases. Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. The number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. In some instances, associated pilar abnormalities have been reported. The follicular structures were dilated and showed infundibular type keratinization and there were numerous mature sebaceous lobules radiating from them resembling the histology of a folliculosebaceous cystic hamartoma (FSCH) or a sebaceous trichofolliculoma. 2 cases of NLS with FSCH have been previously reported. Our cases represent examples of a very rare hamartomatous cutaneous lesion composed of mesenchymal and epithelial components
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