Abstract
Potent antiretroviral regimens are associated with transient flares of hepatitis C virus (HCV) replication in coinfected individuals; this, together with direct hepatotoxicity from antiretroviral medications, may contribute to the progression of hepatic fibrosis in these patients. In a cross-sectional study, a single pathologist evaluated liver specimens biopsied from HIV/HCV-coinfected patients in order to determine the extent of hepatic fibrosis and its progression rate. Patients with stage F3 (numerous septa with architectural distortion without cirrhosis) or stage F4 (definitive or probable cirrhosis) findings …
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