Never miss uveal lymphoma

Abstract

AbstractPurpose Primary intraocular lymphomas can mimic many other diseases. The purpose of this presentation is to underline the crucial importance of biopsy.Methods We described two cases of atypical primary uveal lymphomas.Results The first case concerned a 35 year‐old man who presented a painful intraocular tumor with ciliary body infiltration. Enucleation was performed because of high suspicion of melanoma. Pathological findings revealed MALT lymphoma. No other localization was found and no further treatment was done. The second case concerned a 49 year‐old woman who presented blurred vision secondary to a choroidal mass associated with choroidal yellow infiltrates in right eye. An internal chorioretinal biopsy was performed, leading to the diagnosis of diffuse large B cell lymphoma. This high‐grade lymphoma was treated with chemotherapy associated with radiotherapy.Conclusion These two cases illustrate the variety of clinical features of uveal lymphomas, which can mimic choroidal melanoma as in our first case. In our second case, histological findings were not typical and required an aggressive treatment. Biopsy and histological analysis remains the only way to diagnose a primary uveal lymphoma especially in cases of atypical presentation.