Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO).

Guanghao Qin,Qingchi Yao,Emmanuel Eric Pazo,Hongda Zhang,Wei He,Fang He,Ling Xu,Tiezhu Lin,Guangzheng Dai,Antonio Pinna

doi:10.1371/journal.pone.0263587

Abstract

To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). This retrospective study assessed 41 RAO, 50 RVO and 50 control (age and gender matched senile cataract) participants. The NLR, PLR and MHR parameters of patients' peripheral blood were analyzed. A receiver operating characteristics (ROC) curve analysis and the best cutoff value were used to specify the predictive value of NLR, PLR and MHR in RAO and RVO. The NLR, PLR and MHR were significantly higher in RAO group compared to the control group (p<0.001, p<0.001 and p = 0.008; respectively). The NLR, PLR and MHR were also significantly higher in the RVO group compared to the control group (p<0.001, p = 0.001 and p = 0.012, respectively). The NLR and PLR were significantly higher in the RAO group compared to the RVO group (p<0.001 and p = 0.022, respectively). The optimal cut-off value of NLR to predict RAO was >2.99, with 90.2% sensitivity and 100% specificity. The PLR to predict RAO was > 145.52, with 75.6% sensitivity and 80.0% specificity. Higher NLR, PLR and MHR are related to the occurrence of RAO and RVO. NLR and PLR are more prominent in RAO compared to RVO.

Highlights

Retinal vascular occlusion, which comprises retinal artery occlusion (RAO) and retinal vein occlusion (RVO), is the second most frequent kind of retinal vascular disease after diabetic retinopathy [1]
The neutrophil to lymphocytes ratio (NLR), platelet to lymphocyte ratio (PLR) and monocyte to high-density lipoprotein ratio (MHR) were significantly higher in RAO group compared to the control group (p
The NLR, PLR and MHR were significantly higher in the RVO group compared to the control group (p

Summary

Introduction

Retinal vascular occlusion, which comprises retinal artery occlusion (RAO) and retinal vein occlusion (RVO), is the second most frequent kind of retinal vascular disease after diabetic retinopathy [1]. Since various studies have reported a high risk of stroke and other cardiovascular events in patients associated with acute RAO, and the risk of stroke is determined to be highest within the initial few days after the onset of visual loss [4], RAO is considered an ophthalmic emergency and an analogue to ocular stroke. A ten-year retrospective study of intravitreal dexamethasone implant (Ozurdex) for RVO discovered that this anti-inflammatory medication had considerable anatomic advantages [12]. As a putative biomarker of inflammation, the platelet to lymphocyte ratio (PLR) is linked to the severity of coronary atherosclerosis [18]. Several studies have recently discovered different possible biomarkers for predicting RAO or RVO from normal blood analysis. The monocyte to high-density lipoprotein ratio (MHR), rather than PLR, may be a useful predictor for the development of RAO [24,25,26]

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