Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients. Methods: Clinical data of 156 patients managed for HNSCC at two head and neck surgery centres were analyzed retrospectively. We studied the relationships between survival and PLR as well as NLR. Results: With regards to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant (p = 0.004), and we found the same for disease-free survival (p = 0.05), and tumour-specific mortality (p = 0.009). Concerning NLR, the difference in tumour-specific survival was statistically significant (p = 0.006). According to the multivariate analysis, NLR values higher than the threshold indicated an enhanced risk for overall as well as for tumour-specific mortality. Conclusion: In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival.
Highlights
Head and neck squamous cell carcinoma (HNSCC) of mucosal origin is the sixth most common malignancy, with an estimated 900,000 new cases and about 350,000 fatalities a year worldwide [1].The availability of an easy-to-determine prognostic factor could improve the effectiveness of individualized therapy.Certain formed elements of the blood, as well as their ratios, can be used to establish the diagnosis and to predict prognosis.Int
We studied the correlation between the combination of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) values and five-year mortality
Patients with a high platelet count are at an increased risk of cancer, as well as certain malignancies which exhibit a closer relationship with thrombocytosis [22,23]
Summary
Head and neck squamous cell carcinoma (HNSCC) of mucosal origin is the sixth most common malignancy, with an estimated 900,000 new cases and about 350,000 fatalities a year worldwide [1].The availability of an easy-to-determine prognostic factor could improve the effectiveness of individualized therapy.Certain formed elements of the blood, as well as their ratios, can be used to establish the diagnosis and to predict prognosis.Int. Head and neck squamous cell carcinoma (HNSCC) of mucosal origin is the sixth most common malignancy, with an estimated 900,000 new cases and about 350,000 fatalities a year worldwide [1]. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients. Results: With regards to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant Concerning NLR, the difference in tumour-specific survival was statistically significant According to the multivariate analysis, NLR values higher than the threshold indicated an enhanced risk for overall as well as for tumour-specific mortality. Conclusion: In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival
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