Abstract
Meeting abstracts Myeloid derived suppressor cells (MDSC) are detected at elevated levels in the peripheral blood mononuclear cells (PBMC) of human renal cell carcinoma (RCC) patients and have been shown to mediate tumor growth by promoting angiogenesis and immune suppression (Zea et al., 2005, Ko
Highlights
Myeloid derived suppressor cells (MDSC) are detected at elevated levels in the peripheral blood mononuclear cells (PBMC) of human renal cell carcinoma (RCC) patients and have been shown to mediate tumor growth by promoting angiogenesis and immune suppression (Zea et al, 2005, Ko et al, 2009)
Less is known regarding the role of neutrophils in promoting tumor growth in RCC patients and their relationship to G-MDSC
We showed that IFNg production of T-cells stimulated with anti-CD3/antiCD28 antibodies (n=4) was suppressed by neutrophils pretreated with SKRC-26b tumor supernatant (TCM) when compared to neutrophils not exposed to TCM
Summary
Myeloid derived suppressor cells (MDSC) are detected at elevated levels in the peripheral blood mononuclear cells (PBMC) of human renal cell carcinoma (RCC) patients and have been shown to mediate tumor growth by promoting angiogenesis and immune suppression (Zea et al, 2005, Ko et al, 2009). Neutrophils from renal cell carcinoma patients show increased expression of immunosuppressive and angiogenic gene profile
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