Abstract
BackgroundBehçet’s disease (BD) is an autoinflammatory disorder. Disease activity could be detected by changes in peripheral blood cell components. The aim of this study was to assess the relationship between neutrophil-to-lymphocyte ratio (NLR) with disease activity and carotid intima-media thickness (cIMT) in patients with BD.Patients and methodsThis study was conducted on 20 adult patients with BD (group I). This group was subdivided according to cIMT into group Ia, which included patients with increased cIMT, and group Ib, which included patients with cIMT within normal ranges. Moreover, 20 age-matched and sex-matched apparently healthy volunteers were included as a control group (group II). Patients with BD were subjected to full history taking, thorough clinical examination, and assessment of disease activity according to Behçet’s Disease Current Activity Form score. The white blood cell count, neutrophil count, and lymphocytes count were recorded, and NLR was calculated. cIMT assessment was done for all participants.ResultsThere were statistically significant differences (P< 0.05) regarding lymphocytes count and NLR and highly statistically significant difference (P< 0.001) regarding neutrophil count, being higher in patients with BD. There was a statistically highly significant difference (P< 0.001) regarding cIMT, being higher in group Ia patients (0.82±0.03) than group Ib patients (0.50±0.04) and healthy control group (0.47 ±0.04). There was a statistically significance positive correlation (R=639, P=0.005) between NLR and Behçet’s Disease Current Activity Form score. In conclusion, higher NLR values were recorded in patients with BD. Furthermore, patients with active BD had higher NLR values than inactive, and NLR is higher in patients with increased cIMT; thus, NLR may be an important bio-index for detecting BD activity and the presence of vascular affection.
Highlights
Behçet’s disease (BD) is a relapsing systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, and ocular inflammation
Which are factors not related to inflammation, neutrophil-to-lymphocyte ratio (NLR) is not affected [3]
Laboratory procedures included the following: The aim of this study was to assess the relationship between NLR with disease activity and carotid intimamedia thickness in patients with BD
Summary
Behçet’s disease (BD) is a relapsing systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, and ocular inflammation. Which are factors not related to inflammation, neutrophil-to-lymphocyte ratio (NLR) is not affected [3]. As a traditional inflammatory index, it has been proved to be associated with disease activity and prognosis of various inflammation-related diseases, such as sepsis, autoimmune disease, and cancer [4]. Disease activity could be detected by changes in peripheral blood cell components. The aim of this study was to assess the relationship between neutrophil-to-lymphocyte ratio (NLR) with disease activity and carotid intima-media thickness (cIMT) in patients with BD. Patients and methods This study was conducted on 20 adult patients with BD (group І) This group was subdivided according to cIMT into group Іa, which included patients with increased cIMT, and group Іb, which included patients with cIMT within normal ranges. The white blood cell count, neutrophil count, and lymphocytes count were recorded, and NLR was calculated. The white blood cell count, neutrophil count, and lymphocytes count were recorded, and NLR was calculated. cIMT assessment was done for all participants
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