Abstract
BackgroundPsoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis.MethodsA total of 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular psoriasis (GPP, n = 37), erythrodermic psoriasis (PsE, n = 45), arthritic psoriasis (PsA, n = 25) and mixed psoriasis (n = 23), and 954 healthy control subjects were included in the study. Demographic, clinical, and laboratory information were collected and compared between subgroups.ResultsCompared with the healthy control group, patients with psoriasis had higher total white blood cell (WBC), neutrophil, platelet counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), but lower hemoglobin (Hb) levels, lymphocyte and red blood cell (RBC) counts. NLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups, with GPP group being the highest. PLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups. There was no significant correlation between the psoriasis area severity index (PASI) score and either the NLR or PLR in the PsV group.ConclusionsElevated NLR and PLR were associated with psoriasis and differed between subtypes, suggesting that they could be used as markers of systemic inflammation in psoriasis patients.
Highlights
Psoriasis is a chronic immune‐mediated skin disorder
The same differences were observed between the control group and each of the Generalized pustular psoriasis (GPP), Erythrodermic psoriasis (PsE), and PsA groups, with the exception that platelet counts were significantly higher in the GPP, PsE, and PsA subgroups compared with the control group (Table 2)
Our study is consistent with the results of previous studies of smaller patient populations, and we extended the findings to include a comprehensive and systematic evaluation of the association between psoriasis and multiple hematological parameters, including absolute blood cell counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)
Summary
Systemic inflammation plays an important role in the pathogenesis of psoriasis. Immune-mediated disorder that can involve the skin and/or joints [1]. The psoriasis area severity index (PASI), which evaluates the degree of erythema, induration, and desquamation in the affected body areas, is one of the most commonly used scales to classify disease severity in patients with PsV, but the Systemic inflammation plays an important role in the pathogenesis of psoriasis, and numerous inflammatory mediators have been implicated, including interleukins (e.g., IL-17, IL-1β), other cytokines and chemokines, and serum autoantibodies [4, 5]. NLR and PLR have been identified as potential diagnostic and prognostic markers of other chronic inflammatory diseases and cancers [3, 8,9,10]. Several studies have described the relationship between NLR, PLR, and psoriasis severity [11, 12]
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