Abstract
Recruitment of neutrophils from the intravascular compartment into injured tissue is an essential component of the inflammatory response. It involves intracellular trafficking of vesicles within neutrophils and endothelial cells, both containing numerous proteins that have to be distributed in a tightly controlled and precise spatiotemporal fashion during the recruitment process. Rab proteins, a family of small GTPases, together with their effectors, are the key players in guiding and regulating the intracellular vesicle trafficking machinery during neutrophil recruitment. This review will provide a short overview on this process and highlight new findings as well as current controversies in the field.
Highlights
Haematologists have applied histology to distinguish white blood cell populations from each other
Neutrophil function, which heavily relies on various proteins that are pre-stored in intracellular vesicles, depends on a tightly regulated machinery for the secretion of its granule content
As described in this review, Rab proteins take an important part in regulating the mobilization of neutrophil recruitment-relevant adhesion and activation proteins that are contained in specific granules/vesicles of neutrophils
Summary
Haematologists have applied histology to distinguish white blood cell populations from each other. It involves intracellular trafficking of vesicles within neutrophils and endothelial cells, both containing numerous proteins that have to be distributed in a tightly controlled and precise spatiotemporal fashion during the recruitment process.
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