Abstract
Objective. To assess the possibility of using blood neutrophil reactivity parameters to monitor the inflammatory process in patients with rheumatoid arthritis (RA).Materials and methods. The parameters of the functional activity of neutrophils (netosis activity, absorbing capacity, production of active oxygen species and nitric oxide) were assessed in 61 patients with a verified RA diagnosis in the dynamics of inflammatory process.Results. In the patients, the values of netosis parameters (NETSP30, NETCT30, NETSP150, NETST150) and oxygen-producing activity (NSTSP) are increased during the exacerbation period compared to the clinical improvement phase. The threshold values of the parameters were determined using the categorical regression analysis, on the basis of which an assessment scoring system of the activity of inflammation in patients with RA has been proposed.Conclusion. The parameters for evaluating the functional activity of neutrophils (NETSP30, NETST30, NETSP150, NETST150 and NSTSP) are additional laboratory criteria for assessing the activity of inflammation in RA.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.