Neutrophil reactivity parameters in monitoring inflammation in rheumatoid arthritis

Abstract

Objective. To assess the possibility of using blood neutrophil reactivity parameters to monitor the inflammatory process in patients with rheumatoid arthritis (RA).Materials and methods. The parameters of the functional activity of neutrophils (netosis activity, absorbing capacity, production of active oxygen species and nitric oxide) were assessed in 61 patients with a verified RA diagnosis in the dynamics of inflammatory process.Results. In the patients, the values of netosis parameters (NETSP30, NETCT30, NETSP150, NETST150) and oxygen-producing activity (NSTSP) are increased during the exacerbation period compared to the clinical improvement phase. The threshold values of the parameters were determined using the categorical regression analysis, on the basis of which an assessment scoring system of the activity of inflammation in patients with RA has been proposed.Conclusion. The parameters for evaluating the functional activity of neutrophils (NETSP30, NETST30, NETSP150, NETST150 and NSTSP) are additional laboratory criteria for assessing the activity of inflammation in RA.