Abstract
BackgroundThe purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically.MethodsIn total, 135 colon cancer patients (stage I–III) undergoing curative laparoscopic surgery between January 2004 and December 2013 were enrolled in this study. We collected data on clinicopathological factors, laboratory data on pre and postoperative day 3 (POD3) and tumor markers levels to assess the relation to surgical site infection (SSI) including with anastomotic leakage (AL).ResultsSSI and AL occurred in 16 cases (5.6%) and 4 cases (3%), respectively. SSI and AL were not association with clinicopathological factors. Within laboratory data and tumor markers preoperatively, high neutrophil counts were significantly associated with SSI (P < 0.05) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.656 and 0.854, respectively. In addition, high neutrophil counts on POD3 also were significantly associated with SSI (P < 0.01) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.747 and 0.832, respectively.ConclusionNeutrophil count on pre and POD3 are potentially valuable indicators of SSI including with AL in colon cancer patients undergoing curative surgery laparoscopically.
Highlights
The purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically
Of the 135 registered colon cancer patients, 9 (6.6%) had tumors located in the cecum, 66 (48.8%) in ascending colon, 10 (7.4%) in transverse colon, 14 (10.3%) in descending colon, and 36 (26.6%) in sigmoid colon
Current study showed that presurgical and postoperative day 3 (POD3) high neutrophil counts can help distinguish colon cancer patients after curative laparoscopies with SSIs and AL from those without SSIs and AL (Cut-off values of presurgical neutrophil count for SSIs and AL are 3990 and 5300, respectively; Cut-off values of POD3 neutrophil count for SSIs and AL are 5290 and 5720, respectively)
Summary
The purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically. Surgical site infection (SSI) is the most common complication after digestive tract surgery, despite advances in surgical techniques [1]. Laparoscopic surgery greatly reduces the risk of SSI compared with open surgery [6]. Imai et al demonstrated that open operative procedures in colon cancer cases to be a risk factor for SSI, whereas laparoscopic surgery was associated with a significantly lower risk of SSI [7]. Independent evaluation of SSI risk factors in patients with colon cancer who undergo laparoscopic surgery is important. We investigated factors that might facilitate early diagnosis of SSI and AL after laparoscopic colon cancer surgery Independent evaluation of SSI risk factors in patients with colon cancer who undergo laparoscopic surgery is important. (2020) 20:5
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