Abstract
Materials and Methods 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers. Results Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. Conclusion Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.
Highlights
Throughout the world remains a high mortality rate among adult patients with community-acquired pneumonia (CAP)
It is known that the activation of neutrophils, generation of reactive oxygen species (ROS), and secretion of granules with antimicrobial proteins play a major role in eliminating pathogenic microorganisms
The study included 51 patients diagnosed with community-acquired pneumonia and 14 patients with secondary home pneumonia on a background of chronic obstructive pulmonary disease (COPD) of moderate severity and type 2 respiratory failure
Summary
Throughout the world remains a high mortality rate among adult patients with community-acquired pneumonia (CAP). The study of changes in the functional and metabolic status of neutrophils is one of the most urgent areas of research, since their condition largely determines the development and outcome of acute pneumonia [4]. Community-acquired pneumonia (CAP) has a high mortality rate among adult patients throughout the world. Neutrophils are one of the most urgent areas of research, since their condition largely determines the development and outcome of acute pneumonia. Significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease
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