Abstract
The neutrophil surface carbohydrate groups Lewisx and sialyl Lewisx have previously been shown to interact with the vascular selectins E- and P-selectin. However, the proteins expressing these carbohydrate groups have not been fully characterised. We show that these carbohydrate groups, and the structurally related Lewisa group, are all carried predominantly on a sub-population of the carcinoembryonic antigen (CEA) related NCA-160, which is also recognised by CD66 antibodies. We demonstrate that the related NCA-160, NCA-90/95 and CD67 all undergo an increase in surface expression in response to fMLP stimulation, and that this increase is greater than that observed for the sialyl and non-sialyl Lewisx carbohydrate groups. These data suggest that the expression of differently glycosylated forms of NCA is independently regulated.
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