Neutrophil lymphocyte ratio (NLR) is inversely proportional to cycle threshold value of orf1a gene in RTPCR may be used as biomarker in Covid19 patients

Abstract

Corona virus disease (COVID-19) is an infectious disease caused by a newly discovered corona virus. The virus that causes COVID-19 is mainly transmitted through droplets generated when an infected person coughs, sneezes, or exhales. These droplets are too heavy to hang in the air, and quickly fall on floors or surfaces. A person can be infected by breathing in the virus if the person is within close proximity of someone who has COVID-19, or by touching a contaminated surface and then your eyes, nose or mouth. This study was conducted to find the correlation between Neutrophil Lymphocyte Ratio (NLR) and Cycle Threshold Values of RTPCR in Covid-19 infected patients. This study was conducted in a Diagnostic Centre, located in Kolkata. Data was collected from patients of Covid-19 between October’20to December’20, positive for Covid-19 Infection. Basic demographic data was collected from Laboratory Information System (LIS) of the diagnostic centre. Whole blood EDTA sample were collected to analyze the features of WBC (Neutrophil and Lymphocyte) Total 500 patients were studied for hematological parameters (NLR). Demographic data revealed age range from 10 years to 80 years. Males constituted 360(72%) and females 140(28%). Leukocyte Count showed Leucocytosis was observed in 60% of patients, high absolute neutrophil count in 5%, high Neutrophil Lymphocyte Ratio (NLR) in 55% patients.