Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Branch Retinal Vein Occlusion

Dan-Dan Zhu,Xun Liu

doi:10.1155/2019/6043612

Abstract

Purpose. To evaluate the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio(PLR) value in the development of branch retinal vein occlusion (BRVO)patients. Methods. 81 patients with BRVO and 81 age and sex-matched subjects were recruited as the control group. The BRVO diagnosis was confirmed under comprehensive ophthalmologic examinations. NLR and PLR parameters obtained from peripheral blood were recorded. Results. Both the mean NLR and PLR was significantly higher in the BRVO group compared with the control group (p < 0.001). In ROC analysis, the AUC for NLR was 0.82, and NLR of >2.48 predicted BRVO with a sensitivity of 58% and specificity of 98%. The AUC for PLR was 0.78, and PLR of >110.2 predicted BRVO with a sensitivity of 72% and specificity of 72%. Conclusion. The current study demonstrated that BRVO patients had increased NLR and PLR levels compared with control subjects. The NLR and PLR may be used as independent predictors for identifying risk for the development of BRVO.

Highlights

Branch retinal vein occlusions (BRVO) is the second most common category of retinal vascular disease after diabetic retinopathy, which is an important cause of painless visual loss in middle-aged and elderly individuals [1]
We evaluated the importance of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in branch retinal vein occlusion and found that PLR and NLR values were significantly increased in BRVO patients than the control group
NLR and PLR may be the independent predictors of BRVO. ese data suggest that the inflammatory and thrombotic process might have a crucial role in the incidence of BRVO

Summary

Introduction

Branch retinal vein occlusions (BRVO) is the second most common category of retinal vascular disease after diabetic retinopathy, which is an important cause of painless visual loss in middle-aged and elderly individuals [1]. NLR and PLR values have been recognized as the predictor, treatment response, or prognostic indicators for pretreatment in some types of carcinoma [7,8,9]. Both these prognostic scores have been testified to be involved in thrombotic processes in cardiovascular disease [10, 11]

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