Neutrophil / Lymphocyte and Platelet / Lymphocyte Ratios and Their Relation with Disease Activity in Systemic Lupus Erythematosus Patients

Abstract

Background: systemic lupus erythematosus (SLE) is a chronic disease which had diverse clinical manifestations, course and prognosis. Search for diagnostic markers is continuous process to enhance the diagnostic and treatment process. Aim of the study: this study aimed to investigate correlation between both of neutrophil/lymphocyte and platelet/lymphocyte ratios and disease activity in SLE patients who did not receive any treatment. Patients and Methods: a case control study involving 60 adult SLE patients and 40healthy controls was performed. NLR and PLR levels between SLE patients and healthy controls were compared, and correlations between these indices and clinical characteristics were analyzed. Results: increased NLR and PLR were observed in SLE patients. NLR was positively correlated with erythrocyte sedimentation rate (ESR) (r=0.621, p<0.001) ,SLEDAI scores(r=0. 0.774, p<0.001) and SLICC score(r=0.638, p<0.001). PLR was positively correlated with with erythrocyte sedimentation rate (ESR) (r=0.500, p<0.001),SLEDAI scores(r=0.445, p<0.001). and SLICC score(r=0.377, p<0.001) SLE patients with nephritis had higher NLR and PLR levels than those without nephritis (p<0.001). Conclusion: NLR and PLR could reflect inflammatory response and disease activity and disease damage in SLE patients.