Neutrophil Gelatinase-Associated Lipocalin in chronic heart failure

Abstract

Event Abstract Back to Event Neutrophil Gelatinase-Associated Lipocalin in chronic heart failure Nilgun Isiksacan1*, Murat Koser1, Mehmet Erturk2, Ibrahim Faruk Akturk2, Serkan Yazan2, Mehmet Rifat Yildirim2, Vesile Ornek Diker1 and Ihsan Bakir3 1 Istanbul Mehmet Akif Ersoy Cardiovascular Training and Research Hospital, Central Laboratory, Turkey 2 Istanbul Mehmet Akif Ersoy Cardiovascular Training and Research Hospital, Cardiology, Turkey 3 Istanbul Mehmet Akif Ersoy Cardiovascular Training and Research Hospital, Cardiovascular Surgery, Turkey Introduction Chronic heart failure (CHF) is a progressive and complicated clinical syndrome, it is mostly accompanied by chronic renal disease. Glomerular filtration rate (GFR) is decreased in 30 to 50 % of patients with CHF. NGAL, neutrophil gelatinase-associated lipocalin, which is expressed mainly from neutrophils as a response to bacterial infections in innate immunity, is a new marker for renal function. The aim of this study is to evaluate the renal functions of the patients with CHF and determining the clinic importance of NGAL parameter as a biomarker in CHF. Material and Method Hundred patients (mean age: 67 ± 12 years) from cardiology outpatient clinic diagnosed as CHF enrolled to this study. Creatinine, CRP, BUN and NGAL levels were measured from venous blood samples in 2 hours after collection. According to CRP results, a possible bacterial infection is excluded. All the cases received written inform on the study including Ethics Committee Approval before the study was initiated. Spearman Correlation Analysis is performed. Results Patients with high CRP levels were excluded and NGAL levels did not correlate with normal CRP results(r=0.093, p=0.364). A weak correlation but a statistically significance was observed between NGAL and BUN levels (r=0.293, p=0.03). Also a correlation and a highly statistically significance was found between NGAL and creatinine (r=0.520, p<0.001). Conclusion In this study NGAL performance was found significantly better than BUN. A good correlation between NGAL and creatinine indicates that NGAL may be a candidate biomarker for renal functions in patients with CHF. References 1- Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery. Seitza S, Rauh M, Gloeckler M, Cesnjevard R, Dittricha S, Kocha AME. Swiss Med Wkly. 2013;143:w13744. 2- Neutrophil Gelatinase-Associated Lipocalin (NGAL) predicts renal injury in acute decompensated cardiac failure: a prospective observational study. Macdonald S, Arendts G, Nagree Y, Xu XF. BMC Cardiovascular Disorders 2012, 12:8. Keywords: NGAL, CHF, Neutrophil, Renal functions, Creatinine Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Isiksacan N, Koser M, Erturk M, Akturk I, Yazan S, Yildirim M, Ornek Diker V and Bakir I (2013). Neutrophil Gelatinase-Associated Lipocalin in chronic heart failure. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00108 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Nilgun Isiksacan, Istanbul Mehmet Akif Ersoy Cardiovascular Training and Research Hospital, Central Laboratory, Istanbul, Turkey, nisiksacan@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nilgun Isiksacan Murat Koser Mehmet Erturk Ibrahim Faruk Akturk Serkan Yazan Mehmet Rifat Yildirim Vesile Ornek Diker Ihsan Bakir Google Nilgun Isiksacan Murat Koser Mehmet Erturk Ibrahim Faruk Akturk Serkan Yazan Mehmet Rifat Yildirim Vesile Ornek Diker Ihsan Bakir Google Scholar Nilgun Isiksacan Murat Koser Mehmet Erturk Ibrahim Faruk Akturk Serkan Yazan Mehmet Rifat Yildirim Vesile Ornek Diker Ihsan Bakir PubMed Nilgun Isiksacan Murat Koser Mehmet Erturk Ibrahim Faruk Akturk Serkan Yazan Mehmet Rifat Yildirim Vesile Ornek Diker Ihsan Bakir Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.