Abstract
A 62-year-old man with well-controlled HIV infection presented to Columbia University Medical Center (New York, NY, USA) in December, 2016, with progressive fatigue. He was found to have a haemoglobin concentration of 5·0 g/dL, with laboratory evidence of haemolytic anaemia. Polyspecific direct antibody testing (DAT; also known as direct Coombs testing) was negative. Evaluation of a peripheral blood film revealed the findings presented in the figure. His home medications included his HIV anti-retroviral therapy, along with trimethoprim-sulfamethoxazole (160 mg and 800 mg orally three times a week) for Pneumocystis pneumonia prophylaxis.
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