Abstract
Immunometabolism Neutrophils are short-lived and require rapid access to adenosine triphosphate (ATP) through glycolysis for energy-intensive responses such as migration, pathogen control, and apoptosis. Sadiku et al. describe the metabolic processes that enable this specialization. The authors found that neutrophils cycle between gluconeogenesis and glycogenesis to maintain a consistent supply of ATP even when glucose is limited, such as at sites of infection. This process is dynamically regulated; for example, altitude-induced hypoxia in humans leads to increased glycogen storage in neutrophils. Furthermore, neutrophils from patients with chronic obstructive pulmonary disease show defective glycogen cycling, a phenomenon that is associated with impaired bacterial killing of Streptococcus pneumoniae and accelerated apoptosis. Cell Metab. 10.1016/j.cmet.2020.11.016 (2020).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
