Neutrophil-activating peptide ENA-78.

Abstract

Neutrophil-activating peptide ENA-78 was recently isolated from a human type II-like epithelial cell line A549 (1). ENA-78 is a peptide of 78 amino acids and belongs to the C-X-C supergene family of the chemotactic cytokines (now called chemokines). The C-X-C family contains five other peptides with neutrophil-activating properties, interleukin-8 (IL-8) (2), three closely related members of the GRO family, GROα, GROβ and GROγ (3,4) and neutrophil-activating peptide 2 (NAP-2) (5). Two other members of the same subfamily, platelet factor 4 and interferon-γ induced peptide 10 (γ-IP10) have been shown not to be active on human neutrophils (6,7).KeywordsIdiopathic Pulmonary FibrosisHuman NeutrophilAdult Respiratory Distress SyndromeChemotactic CytokineNeutrophil Chemotactic FactorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.