Abstract

In this paper we treat the thermotropic phase behavior of phosphatidylinositol 4,5-bis(phosphate) (PIP2) aggregates in aqueous solution. By using the solvent contrast variation method in neutron small-angle scattering we could determine the absolute value of the PIP2 molecular volume in the micellar form from the contrast matching point. The shift of the contrast matching point indicates the increase of the PIP2 molecular volume of ∼11% with elevating temperature from 10 °C to 50 °C. The decrease of the gyration radius of the PIP2 micelle observed in the present experiments well agrees with our previous results of X-ray scattering study. The present results suggest that the increase of the molecular volume would be mainly attributable to the change of the hydrophilic polar head region to decrease the critical packing parameter.

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