Abstract
The vortex fluidic device (VFD) is a thin film microfluidic platform which has a wide range of applications in synthesis and other areas of science, and it is important to understand the nature of the thin film of liquid in its inclined rapidly rotating tube. Neutron imaging has been used to determine the thickness of the film in a quartz tube with its shape modelled mathematically, showing good agreement between the model and experiments. The resultant equations are useful for studying VFD mediated processing in general, for which the optimal tilt angle of the tube is typically 45°. This includes its utility for the intelligent scale-up of organic syntheses, as demonstrated in the present study by the scaling up of an imine and amide synthesis to >1 g/min.
Highlights
The vortex fluidic device (VFD) is a thin film microfluidic platform which has a wide range of applications in synthesis and other areas of science, and it is important to understand the nature of the thin film of liquid in its inclined rapidly rotating tube
The vortex fluidic device (VFD) (Fig. 1) is a remarkably versatile thin film processing platform, which can operate under continuous flow conditions, where scalability of any process is considered at the inception of the science, as well as for small volumes in its so called confined mode[1]
The derivation of these equations allows quantitative answers to questions regarding the maximum volume the tube can hold in confined mode, as well as the selection of operating conditions to give the desired residence time under continuous flow, allowing the intelligently-designed scale-up of chemical reactions
Summary
The vortex fluidic device (VFD) is a thin film microfluidic platform which has a wide range of applications in synthesis and other areas of science, and it is important to understand the nature of the thin film of liquid in its inclined rapidly rotating tube. In order to calculate the residence time and better understand and design the processing, it is necessary to understand the shape of the film and how this is influenced by rotational speed, tilt angle, as well as the volume of liquid in the tube.
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