Abstract
The silver accumulation in different tissues of female mice and their offspring after prolonged oral administration of silver nanoparticles to the females during pregnancy and lactation was investigated. Silver content in different organs (blood, liver, brain, kidney and lungs) was determined by means of neutron activation analysis. According to the obtained data silver nanoparticles are able to reach and cross the placental barrier and blood-to-brain barrier in both mice female and their offspring. In mice female the highest silver concentration was determined in lungs, followed by brain, liver, kidney and blood. In offspring silver bioaccumulation changed in the following order lungs > brain > blood > liver > kidney. The average specific mass content of silver which crossed the blood–brain barrier was 373 ± 75 ng (for female) and 385 ± 57 ng (for offspring). The obtained results are important for studies in developmental and reproductive toxicity of nanomaterials.
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