Abstract
We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012–2013. Neutralizing antibodies against Fermon and the dominant 2014 Missouri isolate were universally detected. Titers increased with age. Widespread circulation of enterovirus D68 occurred before the 2014 outbreak. Research is needed to determine a surrogate of protection.
Highlights
We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012– 2013
The Study We assessed the prevalence of enterovirus D68 (EV-D68) neutralizing antibody in the Kansas City population before the 2014 outbreak using deidentified banked serum samples collected in 2012 (n = 155) and 2013 (n = 281) from healthy persons >2 years
All serum samples had neutralizing antibody against the major EV-D68 isolates circulating in the United States in 2014, and most had antibody to the other 2 less frequently detected isolates that year (Figure 2; Appendix Figure)
Summary
We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012– 2013. The Study We assessed the prevalence of EV-D68 neutralizing antibody in the Kansas City population before the 2014 outbreak using deidentified banked serum samples (stored at The Children’s Mercy Hospital) collected in 2012 (n = 155) and 2013 (n = 281) from healthy persons >2 years Sex, and race/ethnicity distributions matched 2010 Kansas City census data (Appendix, https://wwwnc.cdc.gov/EID/ article/25/3/18-0960-App1.pdf) [6].
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