Abstract
SARS-CoV-2 Delta (B.1.617.2) variant of concern (VOC) and other VOCs are spreading in Europe. Micro-neutralisation assays with sera obtained after Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in 36 healthcare workers (31 female) demonstrated significant fold change reduction in neutralising titres compared with the original virus: Gamma (P.1) 2.3, Beta (B.1.351) 10.4, Delta 2.1 and 2.6. The reduction of the Alpha (B.1.1.7) variant was not significant. Despite being lower, remaining neutralisation capacity conferred by Comirnaty against Delta and other VOCs is probably protective.
Highlights
Since its emergence, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been responsible for more than 170 million cases and 3.5 million deaths
We describe the neutralising response of sera from healthcare workers without prior SARS-CoV-2 infection following a second vaccine dose against viral isolates of the Delta variants of concern (VOC), and compared it to the response against isolates of the original, the Alpha, Beta and Gamma VOCs
Amino acid substitutions of the Delta isolates), were further analysed together with additional global sequences downloaded from the Global initiative on sharing all influenza data (GISAID) hCoV19 database identified as belonging to several main variants originating in India – Delta, Kappa (B.1.617.1), as well as the non-VOC B.1.617.3 and B.1.618, and their background lineage B.1
Summary
Citation style for this article: Lustig Yaniv, Zuckerman Neta, Nemet Ital, Atari Nofar, Kliker Limor, Regev-Yochay Gili, Sapir Einav, Mor Orna, Alroy-Preis Sharon, Mendelson Ella, Mandelboim Michal. Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel. Micro-neutralisation assays with sera obtained after Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in 36 healthcare workers (31 female) demonstrated significant fold change reduction in neutralising titres compared with the original virus: Gamma (P.1) 2.3, Beta (B.1.351) 10.4, Delta 2.1 and 2.6. We describe the neutralising response of sera from healthcare workers without prior SARS-CoV-2 infection following a second vaccine dose against viral isolates of the Delta VOC, and compared it to the response against isolates of the original, the Alpha, Beta and Gamma VOCs
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