Abstract
We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance.
Highlights
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf
We present a non-parametric and computationally-efficient method named NeuroXidence that detects coordinated firing within a group of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance
NeuroXidence [1] considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity
Summary
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf . Address: 1Max-Planck Institute for Brain Research & Frankfurt Institute for Advanced Studies, Frankfurt, Germany and 2Department of Anesthesia, Massachusetts General Hospital & Department of Brain and Cognitive Sciences, MIT, MA, USA
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