Abstract
Objective To evaluate safety of an attenuated Japanese encephalitis virus strain SA14-14-2 (master seed lot) in rhesus by a neurovirulence test.Methods Animals were inoculated with an virulent strain SA14 or the attenuated strain SA14-14-2 of Japanese encephalitis virus by intracranial and intraspinal routes.Clinical signs were observed for 21 days and histopathological examination was performed.Results The rhesuses injected with strain SA14 developed neurotoxic reactions and died.The histopathological results showed severe damage with neuronal cell necrosis in their central nervous systems.Only transient fever and mild inflammatory reaction were observed,and no neuronal cell necrosis was found in the animals receiving the attenuated SA14-14-2 virus.Conclusion The neurovirulence of strain SA14-14-2 is remarkably attenuated and the strain is safe in rhesus. Key words: Japanese encephalitis vaccines; Encephalitis virus, Japanese; Virulence; Macaca mulatta
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