Abstract
There is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dynamic wavelet transform coherence (WTC) analysis irrespective of different aEEG algorithms. As an extended study, the current paper examines whether the variability in processed EEG and amplitude-EEG (aEEG) outputs would impact the determination of NVC in newborns with encephalopathy. Concurrent processed EEG tracings and regional near infrared spectroscopy (NIRS)-based cerebral tissue oxygen saturation (SctO2) readings during a period of twenty hours in their first day of life were selected and processed in this study. After bandpass-filtered in 2–15 Hz, rectified, and down-sampled at 0.21 Hz, the processed EEG tracings along with NIRS-SctO2 (0.21 Hz) were used to perform WTC analysis, followed by comparison of WTC-metrics between SctO2-processed EEG coherence and SctO2-aEEG coherence using Bland–Altman statistics. Our results demonstrated high and significant correlation (R2 = 0.96, p < 0.001) between NVC assessments by SctO2-processed EEG and SctO2-aEEG coherence, confirming that band-passed, rectified, and down-sampled processed EEG, or aEEG, can be paired with NIRS-SctO2 to assess NVC in newborns with encephalopathy. Findings indicate the feasibility of a simpler approach to NVC in neonates by using directly processed EEG, instead of aEEG.
Highlights
Asphyxia impairs fetal cerebral blood flow and is manifested postnatally by neonatal encephalopathy (NE) using the clinical Sarnat stages
We examine the rigor and consistency of the novel neurovascular coupling (NVC) methodology using processed EEG tracings directly from EEG hybrid or from AEEG machines to measure NVC assessment obtained from infants with asphyxia monitored in the first day of life, aiming to compare wavelet transform coherence (WTC)-metrics between SctO2-processed EEG
This example illustrates that even though both output signals were derived from the same raw EEG tracing, the variation between processed EEG and aEEG tracings is visually clear
Summary
Asphyxia impairs fetal cerebral blood flow and is manifested postnatally by neonatal encephalopathy (NE) using the clinical Sarnat stages. The procedure to obtain processed EEG included three simple steps: (1) bandpass-filtering in 2–15 Hz, (2) rectification, and (3) down-sampling at 0.21 Hz to match with the sampling rate of SctO26. This approach may potentially expand or enable a conventional EEG system to simultaneously display continuous EEG (cEEG) and NVC by using processed EEG in real time. We examine the rigor and consistency of the novel NVC methodology using processed EEG tracings directly from EEG hybrid or from AEEG machines to measure NVC assessment obtained from infants with asphyxia monitored in the first day of life, aiming to compare WTC-metrics between SctO2-processed EEG. Coherence and SctO2-aEEG coherence using Bland–Altman statistics, and evaluate agreement between two the NVC assessment tools
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
