Abstract
Neurotropin abrogates lidocaine-induced suppression of neurite growth in cultured rat spinal neurons
Highlights
Neurotropin is an analgesic agent used for the treatment of neuropathic pain, such as lumbago, neck-shoulder-arm syndrome, postherpetic neuralgia [1,2] and fibromyalgia [3], as well as dysesthesia of subacute mylo-optico-neuropathy [4]
Et al [7] showed that neurotropin can ameliorate allodynia in rats and axonal degeneration induced by paclitaxel, an anticancer agent used for ovarian cancer, non-small cell lung carcinoma and breast cancer, in cultured pheochromocytoma cell line and rat dorsal root ganglion neurons, without affecting their chemotherapeutic actions
We investigated the effects of neurotropin on neurite growth in cultured rat embryo spinal neurons
Summary
Neurotropin is an analgesic agent used for the treatment of neuropathic pain, such as lumbago, neck-shoulder-arm syndrome, postherpetic neuralgia [1,2] and fibromyalgia [3], as well as dysesthesia of subacute mylo-optico-neuropathy [4]. Et al [7] showed that neurotropin can ameliorate allodynia in rats and axonal degeneration induced by paclitaxel, an anticancer agent used for ovarian cancer, non-small cell lung carcinoma and breast cancer, in cultured pheochromocytoma cell line and rat dorsal root ganglion neurons, without affecting their chemotherapeutic actions. These studies suggest that neurotropin has analgesic effects and neuroprotective effects. We used the simple preparation of cultured rat spinal neurons to examine the effects of neurotropin and lidocaine on neurite growth and the effects of neurotropin on lidocaine-induced neurotoxicity
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