Abstract
It has become abundantly clear that the ovary is controlled by two systems that act in concert: The pituitary gonadotropins which reach the gland via the blood stream, and an intraovarian complex of regulatory factors, which are produced by the ovary and act in various paracrine, autocrine, and juxtacrine manners. One such factor is nerve growth factor (NGF), which belongs to a family of related target-derived proteins known as neurotrophins (NTs), which are required for the survival and development of discrete neuronal populations in the central and peripheral nervous systems (1, 2). Five NTs have been identified, of which NGF is the best known (1). The rest of the family consists of brain-derived neurotrophic factor (BDNF) (3), neurotrophin-3 (NT-3) (4–6), neurotrophin-4/5 (NT-4/5) (7, 8), and neurotrophin-6 (NT-6) (9). Select members of the neurotrophin family are required for the survival of different and overlapping neuronal populations in both the central and peripheral nervous system.
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