Abstract
1. 1. Serotonin relaxes catch contraction, lowers the critical level for spike discharge and increases the amplitude of the calcium-dependent spike in the anterior byssus retractor muscle (ABRM) of Mytilus edulis L. 2. 2. In the present study, the effect of serotonin on resting membrane potentials was measured in solutions containing various concentrations of Na +, K +, Cl − and Ca 2+ ions. 3. 3. Effects of altering buffer systems and changing pH were also examined. 4. 4. Serotonin had no effect on membrane potential in normal artificial seawater (ASW) or in any of the solutions containing 0 Na +, 0 K +, low and high Ca 2+ and low Cl − (buffered with Tris-HCl). 5. 5. Thus it is unlikely that serotonin causes a selective increase in conductance to Cl −, K + or Na +. 6. 6. In perfusion media containing bicarbonate ion, serotonin hyperpolarized; an effect perhaps related to the influence of HCO − 3 on intracellular pH or Ca 2+ binding.
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