Abstract
A mixed cell nerve tissue culture system from dorsal root ganglia of chick embryos was used to test the effects of tri- o-tolyl phosphate (TOTP), its metabolites and di-isopropylphosphorofluoridate (DFP). Cytotoxic responses consisted of reduction in number and length of nerve fibres and increased vacuolization of neuroglial cells. Unmetabolized TOTP was shown to produce degenerative changes in both nerve fibres and neuroglial cells. Metabolized TOTP and DFP were slightly more potent than TOTP itself. The nerve fibres were generally more sensitive to all treatments than the neuroglial cells. A well defined, sensitive, tissue culture system was shown to yield results after only 3 to 5 days of culture.
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