Abstract
5% ofingested Mn is absorbed and it is rapidly clearedfrom the blood by the liver and excreted in bile. Likeother essential elements, its concentration must becontained within certain limits for optimum fun-ctioning. The relation between manganese intakeand well-being is probably in the form of an invertedU-shaped curve: at lower levels, manifestations ofmanganese deficiency occur, while high levels of Mnexposure are associatedwith neurologic and neurop-sychiatric disorders. To date, we do not know atwhat level of exposure deleterious effects begin tooccur. The dose
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