Abstract
Methods In a retrospective cross-sectional study, parameters of event-related potentials (ERPs) were analysed from patients receiving HAART with ddI, ddC, d4T for at least 3 month (n = 60) with a mean intake of 24 ± 6 months (mv ± 1 SD). Results were compared to a control group receiving HAART without these substances. The latency of P2, N2, P3 and the amplitude of P3 of ERPs and the mean reaction time were analysed. Cognitive impairment (CI) and distal-symmetric polyneuropathy (DSP) were investigated using routine clinical and neurophysiological methods.
Highlights
Toxic effects of highly active antiretroviral therapy (HAART) emerge in all organs and are well known in the peripheral nerve system
Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
Results were compared to a control group receiving HAART without these substances
Summary
Address: 1Department of Neurology – Universtity Hospital of Muenster, Muenster, Germany and 2Department of Internal Medicine D University Hospital of Muenster, Muenster, Germany. Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P163 doi:10.1186/1758-2652-11-S1-P163. Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
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