Abstract
Background: The widespread use of pesticides in public health and agriculture operations has led to significant environmental degradation and potential health risks. It's worth noting that the main reason for toxicity with most pesticides, especially insecticides like is to attack nervous system components. Aim: this study achieved to study the effect of single oral and dermal sub-lethal exposure of abamectin as a neurotoxic compound on acetylcholinesterase (AchE) and oxidative stress biomarkers in male albino rat's brains. Methods: experimental rats were divided into three groups as control, oral and dermal (15 rat each). The tested dose was ½ of LD50 for oral and dermal experiments. Results: single abamectin exposure by oral or dermal is connected with neurotoxicity in exposed rats as evidenced by a marked reduction in. Acetylcholinesterase (AChE) activity and induction of oxidative stress. The oxidative stress biomarkers lipid and protein oxidation (MDA and PC) were significantly increased. While antioxidant biomarkers, glutathione (GSH) glutathione peroxidase (GPx) and superoxide dismutase (SOD) were markedly declined in both oral and dermal exposure. GST was increased markedly in brain tissues. Conclusion: this study through light on neuro and oxidative impact of abamectin after a single exposure (acute effect). SO, awareness of the importance of responsible use of pesticides must be implemented for reducing the hazard impact of agrochemicals.
Highlights
Bio-pesticides among other agrochemicals are widely employed in agriculture to eradicate pests that destroy crops and promote sustainable development (Adu et al., 2019)
The aim of this study is to identify the impact of bio-pesticides through dermal or oral exposure on acetylecholinesterase and oxidative stress biomarkers in brain tissues of male albino rats during the acute toxicity period
Total reduced glutathione (GSH) content and glutathione peroxidase activity were measured by Beutler, et al, (1963) method. abamectin by oral and dermal compared to the untreated group after 1 day of treatment
Summary
Bio-pesticides among other agrochemicals are widely employed in agriculture to eradicate pests that destroy crops and promote sustainable development (Adu et al., 2019) These compounds have the potential to be harmful to some creatures, including persons, and must be handled and safely disposed of (WHO, 2016). It's worth noting that the main reason for toxicity with most pesticides, especially insecticides like is to attack nervous system components (Abdollahi and Karami-Mohajeri 2012; and KaramiMohajeri et al, 2013). The widespread use of pesticides in public health and Received:14/7/2021 Accepted:25/8/2021 Keywords: Abamectin, neurotoxicity, Oxidative Stress, AchE, Oral, Dermal, Rat. agriculture operations has led to significant environmental degradation and potential health risks. Aim: this study achieved to study the effect of single oral and dermal sub-lethal exposure of abamectin as a neurotoxic compound on acetylcholinesterase (AchE) and oxidative stress biomarkers in male albino rat's brains.
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