Neurotherapeutic Comparison of Aripiprazole and Ethanolic Extract of Fragaria Ananassa on Cerebrum and Amygdala of Methamphetamine Intoxicated Male Wistar Rats

Abstract

The obvious need for other effective therapeutic medications for methamphetamine-induced cerebral and amygdala toxicity has warranted this research. _Fragaria ananassa, _extracted ethanolically. The current study looked at the neurotherapeutic effects of the ethanolic extract of _Fragaria ananassa _on the cerebrum and amygdala of methamphetamine-intoxicated Wistar rats. The rats were divided into 8 groups. Oxidative stress markers were analysed, neurobehavioural tests were carried out, and histological examination was done. SPSS version 20.0 was used to analyze the data, with a significance level of 0.05 considered significant. Group A was the control group, and B received 100mg/kg of meth. Group C received 200mg/kg of the ethanolic extract of strawberry. Groups D, E, and F received 100mg/kg of meth and 100mg/kg of the ethanolic extract of strawberry, and, finally, 100mg/kg of meth was treated with 200mg/kg of the ethanolic extract of strawberry and 10mg/kg of aripiprazole, respectively. The correlation between the initial weight and the final weight showed an obvious increase in the weight of the rats, especially in the control group (A) and the F and G groups. The histoarchitecture showed marked degeneration of neuronal cells in group B, which received methamphetamine alone, but knew further improvement in groups that were subsequently treated with the extract. The study further demonstrates that oxidative stress markers (SOD, MDA, CAT) were not significantly altered as long as the ethanolic extracts of strawberry were administered alongside the ingested methamphetamine, in line with other hypotheses.