Abstract
Objective: The presence of serous tubal intraepithelial carcinoma (STIC) in the fallopian tube (FT) is used to designate FT rather than ovary as the site of tumor origin in high-grade serous ovarian carcinomas (HGSOC). Based on gene profiling, we have identified neurotensin (NTS) as significantly over-expressed in HGSOC associated with STIC, but the role of NTS in HGSOC remains unclear. The objective of this study was to investigate the expression of NTS and its receptors in HGSOC and to test whether the neurotensin (NTS)-signaling pathway could be used as a therapeutic target.
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