Abstract
The effects of neurotensin in vitro were investigated on the binding characteristics of N-[ 3 H]propylnorapomorphine ([ 3H]NPA) binding sites in crude membrane preparations from post mortem human caudate-putamen, obtained within 10 h after death from 3 patients without reported neurological or psychiatric diseases. Neurotensin (0.1–30 nM) was found to increase the K d value of [ 3H]NPA binding sites with a maximal increase of about 50% (420±45 pM) at 3 nM of neurotensin, without significantly affecting the B max value (123±20 pmol/g protein). These results indicate the existence of an intramembrane regulation by neurotensin receptors of D 2 receptors in the human caudate-putamen.
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