Abstract
Neurotensin (NT) is a tridecapeptide which has been identified in the central nervous system of all vertebrate classes, having been originally isolated from bovine hypothalamus1,2,3. Using immunohistochemical techniques, NT has been identified within the substance of the substantia nigra (SN), pars compacta, and the ventral tegmental area (VTA)4,5,6,7,8. Recently, NT binding sites have been identified in the VTA with a dissociation content (Kd) of 9.3 ± 0.4 nm and the number of binding sites (Bm) of 86 ± 10 fm/mg protein9. The VTA is found in the mesolimbic dopamine (DA) system within the central nervous system. This mesolimbic system originates in the A8, A9 (SN), and A10 cell bodies, passes along the medial forebrain bundle, and terminates in the limbic structures such as nucleus accumbens (N.ACB), olfactory tubercle, and the amygdala.
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