Neurosyphilis in 37 cases

Abstract

Objective To investigate the clinical manifestations, laboratory tests, imaging features,diagnosis, treatment and prognosis of neurosyphilis.Methods The 37 cases of patients with neurosyphilis admitted in our hospital from 2000 to 2009 were analyzed retrospectively.Results Among the 37cases, the cerebral vascular neurosyphilis in 16 cases, paralytic dementia in 13 cases, spinal cord syphilis in 3 cases, meningeal neural syphilis in 2 cases, asymptomatic neurosyphilis in 2 cases, gumma type in 1case.Serum rapid plasma reagin(RPR)test and treponema pallidum hemagglutination assay(TPHA)test were all positive.the positive rate of cerebrospinal fluid(CSF)the RPR was 67.6%, the TPHA was 100% ,the cerebrospinal fluid examination revealed CSF protein increase was 64.9% and cell number elevation was 54.1%.Conclusions Because of theclinical manifestations of neurosyphilis are complex, the diagnosis should be comprehensive analysis, according to the clinical characteristics, laboratory and imaging features,the cerebrospinal fluid examination is the key.It is should be strived for early diagnosis and treatment to improve prognosis.At the same time, in order to reduce the incidence of neurosyphilis, there should go up to plan and enforce the prevention and treatment of syphilis from the concept of public health. Key words: Treponema pallidum ; NeurosyphilisCerebrospinal fluid ; Public health ;