Abstract
BackgroundThe tumor removal of Cavernous Sinus Meningiomas usually results in severe neurological deficits. Stereotactic radiosurgery (SRS) and fractionated Stereotactic radiotherapy (SRT) are advanced modalities of radiotherapy for treatment of patients with inoperable and symptomatic CSMs. The authors evaluated the long term symptomatology, the image findings, and the toxicity of patients with CSMs treated with SRS or SRT.Patients and methodsFrom 1994 to 2009, 89 patients with symptomatic CSMs were treated with SRS or SRT. The indication was based on tumour volume and or proximity to the optic chiasm. The median single dose of SRS was 14 Gy, while the SRT total dose, ranged from 50.4 to 54 Gy fractionated in 1.8-2 Gy/dose. The median follow-up period lasted 73 months.ResultsThe clinical and radiological improvement was the same despite the method of radiotherapy; 41.6% (SRS) and 48.3% (SRT) of patients treated. The disease-free survivals were 98.8%, 92.3% and 92.3%, in 5, 10, and 15 years, respectively. There was no statistical difference in relation to the symptoms and image findings between both methods. According to the Common Toxicity Criteria, 7% of the patients presented transient optic neuropathy during 3 months (grade 2) and recovered with dexamethasone, 2 patients had trigeminal neuropathy (grade 2) and improved rapidly, and one patient presented total occlusion of the internal carotid artery without neurological deficit (grade 2). Temporary lethargy and headache (grade 1) were the most frequent immediate complications. No severe complications occurred.ConclusionsStereotactic Radiosurgery and fractionated Stereotactic Radiotherapy were equally safe and effective in the management of symptomatic CSMs.
Highlights
The tumor removal of Cavernous Sinus Meningiomas usually results in severe neurological deficits
There was no statistical difference in relation to the symptoms and image findings between both methods
The aim of this paper is to present the results of the treatment with Stereotactic radiosurgery (SRS) or Stereotactic radiotherapy (SRT) of 89 patients with Grade I symptomatic Cavernous sinus meningiomas (CSMs)
Summary
The tumor removal of Cavernous Sinus Meningiomas usually results in severe neurological deficits. Meningiomas account for 13% to 26% of all intracranial neoplasms. Cavernous sinus meningiomas (CSMs) occur in 0.5 per 100,000 persons in the general population. The vast majority of meningiomas are benign, well differentiated, and with low proliferative potential. The most common clinical features of meningiomas are neurological deficits (e.g. amblyopia), epilepsy, and headache. There are an increasing number of asymptomatic patients with CSMs because CT scans or MR is commonly used for evaluation of other medical conditions, as cranial trauma and allows the diagnosis in the preclinical phase. Histological type is the major predictor of meningioma behavior [1]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
