Abstract
According to the results of our laboratory the theory of immune dysfunction, the theory on the genetic architecture of ASD, the disrupted cortical connectivity theory and the theory on the contribution of cerebellum to ASD have shown fundamental experimental evidences to support the core symptoms of the complex and enigmatic physiopathology of autism spectrum disorder. The additional hypothesis about the neurogenesis in the amygdala, the contribution of oxytocin, vasopressin, the mirror neuron network, and mitochondrial dysfunction described are stimulating and interesting approaches that deserve further systematic basic and clinical neuroscience research.
Highlights
In a previous paper [1] (Castejón et al.,2019) we have reported a clinical study on 75 infant patients from 3 to 15 years with autism spectrum disorder in a developing country
We emphasized different phenotype subtypes of autism spectrum disorder (ASD) related with the environmental changes of developing countries and the multiple maternal pathology as risks factor for ASD
The different clinical symptoms found in ASD patients as observed in the present study suggest the dysfunction of a cell energy organelle as mitochondria
Summary
In a previous paper [1] (Castejón et al.,2019) we have reported a clinical study on 75 infant patients from 3 to 15 years with autism spectrum disorder in a developing country. The converging findings of functional connectivity abnormalities and white matter abnormalities in autism suggest that alterations in neural connectivity and the communication between different brain regions may be involved in behavioral and cognitive deficits associated with autism [8].
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