Abstract
Chronic exposure to cocaine results in long-term changes in the central nervous system (CNS). In their Perspective, [Gupta and Tsai][1] discuss new results, reported elsewhere, that elucidate the signaling pathways that promote and dampen down the effects of chronic cocaine on the CNS. They explain the part played by a cyclin-dependent kinase (Cdk5), which is switched on by the DFosB transcription factor and regulates PKA-dependent signaling pathways, resulting in a dampening of the effects of chronic cocaine. [1]: http://www.sciencemag.org/cgi/content/full/292/5515/236
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