Abstract
Ischemic stroke is a consequence of diminished cerebral blood flow to cortical regions, resulting in subsequent reductions in excitability. The brain undergoes immense cortical remapping following a stroke, which can be facilitated by neuronal excitability. However, analyses of electrophysiologic recordings, cortical stimulation, and fMRI reveal a decline in the excitability of the ipsilesional hemisphere following an ischemic stroke and an increase in interhemispheric inhibition by the contralesional hemisphere. Recent findings have implicated non-invasive stimulation with post-stroke recovery through the induction of synaptic plasticity and recruitment of neurotrophic factors to the peri-infarct region. The aim of this paper is to review recent research that has beendevoted to repetitive transcranial magnetic stimulation (rTMS) and its use as a therapeutic tool in motor and speech rehabilitation via the alteration of excitability in the brain post-ischemic stroke.
Highlights
Ischemic stroke is a consequence of diminished cerebral blood flow to cortical regions, resulting in subsequent reductions in excitability
Cortical stimulation, and fMRI reveal a decline in the excitability of the affected hemisphere (AH) following an ischemic stroke.[7]
RTMS offers a revolutionary approach to stroke recovery through direct non-invasive stimulation of the cortex.[11]
Summary
Ischemic stroke is a consequence of diminished cerebral blood flow to cortical regions, resulting in subsequent reductions in excitability.
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