Neuroradiological features of six kindreds with MELAS tRNALeu A3243G point mutation: implications for pathogenesis

Abstract

OBJECTIVETo determine the neuroradiological abnormalities associated with subjects carrying the mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) tRNALeu(UUR)A3243G point mutationMETHODSMitochondrial genetic analysis was performed on 24 subjects from...