Neuropsychological measures and event-related potentials in alcoholics: interrelationships, long-term reliabilities, and prediction of resumption of drinking.

Abstract

Sober male and female alcoholics and peer controls were tested and then retested 14 months later on neuropsychological performance tests (NTP) and also had event-related potentials (ERPs) recorded (non-concurrently) to visual stimulation. Both NTP and ERP measures distinguish male alcoholics from peer controls at test and retest; NTP, but not ERP, scores distinguish female alcoholics from peer controls. Both measures manifest moderate to high reliabilities over time and are correlated modestly. NTP and ERP measures obtained at the end of treatment predict future resumers and abstainers 8 to 14 months later. The results demonstrate the utility of biopsychological approaches to alcoholism and support Grant's (1986) concept of alcoholics as suffering from an intermediate duration (subacute) organic mental disorder.