Abstract
BackgroundCurcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes. Meanwhile, the neuroprotective actions of curcumin have been documented for experimental therapy in Parkinson’s disease (PD).MethodsIn this study, we used a systematic review to comprehensively assess the efficacy of curcumin in experimental PD. Using electronic and manual search for the literatures, we identified studies describing the efficacy of curcumin in animal models of PD.ResultsWe identified 13 studies with a total of 298 animals describing the efficacy of curcumin in animal models of PD. The methodological quality of all preclinical trials is ranged from 2 to 5. The majority of the experiment studies demonstrated that curcumin was more significantly neuroprotection effective than control groups for treating PD. Among them, five studies indicated that curcumin had an anti-inflammatory effect in the PD animal models (p < 0.05). Meanwhile, four studies showed the antioxidant capability of curcumin, by which it protected substantia nigra neurons and improved striatal dopamine levels. Furthermore, two studies in this review displayed that curcumin treatment was also effective in reducing neuronal apoptosis and improving functional outcome in animal models of PD. Most of the preclinical studies demonstrated the positive findings while one study reported that curcumin had no beneficial effects against Mn-induced disruption of hippocampal metal and neurotransmitter homeostasis.ConclusionsThe results demonstrated a marked efficacy of curcumin in experimental model of PD, suggesting curcumin probably a candidate neuroprotective drug for human PD patients.
Highlights
Curcumin, a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes
Results of the search Based on our searches of the electronic databases and after removing reproduction we identified a total of 113 references
After reading the whole text of the remaining 48 studies which reported the efficacy of curcumin in animal models of Parkinson’s disease (PD), we incorporated 13 articles and assessed these for eligibility [11, 13,14,15,16,17,18,19,20,21,22,23,24] (Fig. 1)
Summary
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes. Curcumin (diferuloylmethane) is widely used in Southeast Asia, India and China in food preparation or for medical purposes [6]. It shows anti-oxidant, anti-inflammatory and anti-cancer features. The most pivotal biological function of curcumin related to neuroprotection is its anti-oxidant effect, which can guards substantia nigra (SN) neurons and increases striatal dopamine count and chelates Fe2+ in the 6-OHDA (6-hydroxydopamine) rat models of PD [8]. Several studies in different experimental models of PD have showed neuroprotective effect of curcumin. The aim of this review was to systematicly describe the therapeutic potential of curcumin in animal models of PD and hope to provide more comprehensive assessment of the effects
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