Neuroprotective potential of Zonisamide and Nigella sativa on traumatic brain injury-induced oxidative stress in mice

Abstract

Traumatic brain injury (TBI) is a primary public health concern that has caused millions of deaths and disabilities around the world. Numerous medications are available to relieve TBI-associated complications, but they do not prevent further harm from occurring. As a result, novel therapeutic medicines that protect against neuronal damage as a result of trauma and its repercussions, especially secondary injury, are required. The study used Swiss albino mice (25-30 g) of either sex. TBI was induced by the weight-drop method. Oxidative stress parameters were observed following the administration of zonisamide (100 mg/kg) and Nigella sativa (NS) (300 mg/kg) per se and in combination. The levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were significantly enhanced, but the levels of malondialdehyde (MDA) and Nitrite were significantly reduced by treatment with the mentioned drugs. The results affirmed the potential function of both drugs in preventing TBI-induced oxidative damage.