Neuroprotective Potential of <i>Solanum giganteum</i> Leaves Extracts against Neurotoxin Agents and Oxidative DNA Damage in Rodents

Abstract

Other species of Solanum are evaluated as neuroprotective and have conventionally been applied for the management of CNS disorders; on the other hand, investigational data to support this practice is lacking. Therefore, we aimed to assess the effect of Solanum giganteum leaves extracts aligned with Aluminium chloride-induced memory loss of Alzheimer’s Disease (AD) type within the rats. The work was considered to persuade dementia by chronic administration of aluminium chloride by a dose of 175 mg/kg, p.o. designed for 28 days in rats and rats are separated keen on seven groups, i.e. normal, negative control, standard groups as well as four groups of Solanum giganteum Jacq. (chloroform extract (SGC100 and 200 mg/kg) and alcoholic extract (SGA 250 and 500 mg/kg) p.o.), whereas these groups were treated and examined till the 28th day of an investigational trial. The research’s behavioral, neural, and biochemical characteristics were set up during or after it. DNA fragmentation and histological changes in the brain were also noted. Aluminium chloride on a dose of 175 mg/kg, p. o. had extensively persuaded dementia and Solanum giganteum Jacq. leaves chloroform extract 200 mg/kg p.o., overcomes therapeutic outcome against Aluminium chloride persuaded dementia of AD category in rats. Solanum giganteum Jacq. of chloroform extract makes use of neuroprotective action against AlCl3-induced behavioral considerations such as cognitive deficit and locomotor destruction. Further, Saolnum giganteum Jacq. of chloroform extract was also able to cure oxidative stress and neuroinflammation in the hippocampus and cortical areas, reversing the biochemical abnormalities caused by aluminum.