Neuroprotective Potential of Limonene in LPS induced Parkinson’s Disease in Rats

Abstract

AbstractBackgroundParkinson’s disease is a hypokinetic disorder characterized by selective loss of dopaminergic in the substantia nigra pars compacta (SNPc) region of the mid‐brain. Dopaminergic degeneration of neurons is considered to be due to oxidative stress, neuroinflammation, mitochondrial dysfunction, etc.MethodInfusion of LPS induced motor deficit and increased oxidative–nitritive stress in rats. Chronic treatment with limonene (25, 50 and 100 mg/kg/p.o.) for 21 days. LPS induced motor deficit and increase in striatal oxidative burden.ResultChronic treatment with limonene (25, 50 and 100 mg/kg/p.o.) for 21 days, significantly attenuated motor deficit and increased in striatal oxidative burden. Biochemically limonene significantly reduced the oxidative–nitrative stress, as evidenced by the decrease in malondialdehyde (MDA) and nitrite levels, and restored the reduced catalase, glutathione (GSH), and Superoxide dismutase (SOD) levels.ConclusionThe observed beneficial effects of limonene in motor defects may be due to its ability to reduce oxidative burden.